RSV NS1 (1C) binds TRIM25

Stable Identifier
R-HSA-9717525
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
Synonyms
NS1 binds TRIM25
ReviewStatus
5/5
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RSV NS1 (1C) binds TRIM25
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Human respiratory syncytial virus (RSV) nonstructural 1 (NS1 or 1C) protein has been shown to suppress DDX58 (RIG-1)-mediated type-I interferon (IFN) production in various cells including human epithelial type 2 (HEp-2), human lung carcinoma (A549), and human embryonic kidney 293T (HEK293T) cells (Ban J et al. 2018). Ectopically expressed 1C (NS1) in HEK293T cells was found to target the PRY/SPRY domain of E3 ubiquitin/IFN-stimulated gene 15 (ISG15) ligase tripartite motif–containing protein 25 (TRIM25). The binding to the PRY/SPRY domain prevented the TRIM25-mediated K63-linked ubiquitination of DDX58, which is essential for DDX58 interaction with MAVS (Gack et al, 2007; Ban J et al. 2018).

Structural and biochemical studies suggest that the monomeric form of 1C (NS1) is likely the predominant form (Chatterjee S et al. 2017).

Literature References
PubMed ID Title Journal Year
17392790 TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Gack, MU, Shin, YC, Joo, CH, Urano, T, Liang, C, Sun, L, Takeuchi, O, Akira, S, Chen, Z, Inoue, S, Jung, JU

Nature 2007
30558248 Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling

Ban, J, Lee, NR, Lee, NJ, Lee, JK, Quan, FS, Inn, KS

Viruses 2018
Participants
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Output
Entity On Other Cell
Participates
as an event of
Disease
Cross References
Mondo
Authored
Shamovsky, V  (2021-03-10)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Shamovsky, V  (2021-03-10)
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