RSV NS1 (1C) binds TRIM25

Stable Identifier
R-HSA-9717525
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
Synonyms
NS1 binds TRIM25
ReviewStatus
5/5
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RSV NS1 (1C) binds TRIM25
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Human respiratory syncytial virus (RSV) nonstructural 1 (NS1 or 1C) protein has been shown to suppress DDX58 (RIG-1)-mediated type-I interferon (IFN) production in various cells including human epithelial type 2 (HEp-2), human lung carcinoma (A549), and human embryonic kidney 293T (HEK293T) cells (Ban J et al. 2018). Ectopically expressed 1C (NS1) in HEK293T cells was found to target the PRY/SPRY domain of E3 ubiquitin/IFN-stimulated gene 15 (ISG15) ligase tripartite motif–containing protein 25 (TRIM25). The binding to the PRY/SPRY domain prevented the TRIM25-mediated K63-linked ubiquitination of DDX58, which is essential for DDX58 interaction with MAVS (Gack et al, 2007; Ban J et al. 2018).

Structural and biochemical studies suggest that the monomeric form of 1C (NS1) is likely the predominant form (Chatterjee S et al. 2017).

Literature References
PubMed ID Title Journal Year
17392790 TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Takeuchi, O, Gack, MU, Joo, CH, Inoue, S, Akira, S, Shin, YC, Liang, C, Jung, JU, Sun, L, Urano, T, Chen, Z

Nature 2007
30558248 Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling

Ban, J, Inn, KS, Lee, NR, Lee, NJ, Quan, FS, Lee, JK

Viruses 2018
Participants
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Output
Entity On Other Cell
Participates
as an event of
Disease
Authored
Shamovsky, V  (2021-03-10)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Shamovsky, V  (2021-03-10)
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