SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol

Stable Identifier
R-HSA-9717396
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SCN2A in combination with a regulatory beta subunit responds to depolarization by opening and passively transporting sodium ions according to the concentration gradient from the extracellular region to the cytosol (Ahmed et al. 1992, Ben-Shalom et al. 2017). In mouse type II taste cells, initial depolarization at the apex of the cell is believed to cause an activation potential via Scn2a, Scn3a, and Scn9a located at the basolateral membrane (Gao et al. 2009). Differences in SCN2A alleles appear to be related to autism spectrum disorder (Ben-Shalom et al. 2017).

Literature References
PubMed ID Title Journal Year
28256214 Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures

Ben-Shalom, R, Keeshen, CM, Berrios, KN, An, JY, Sanders, SJ, Bender, KJ

Biol Psychiatry 2017
1325650 Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain

Ahmed, CM, Ware, DH, Lee, SC, Patten, CD, Ferrer-Montiel, AV, Schinder, AF, McPherson, JD, Wagner-McPherson, CB, Wasmuth, JJ, Evans, GA

Proc Natl Acad Sci U S A 1992
Participants
Output
Participates
Catalyst Activity

sodium channel activity of SCN2A:SCN1B,2B,4B [plasma membrane]

Inferred From
Authored
Reviewed
Created
Cite Us!