Reactome | SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol

SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol

Stable Identifier

R-HSA-9717396

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol

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SCN2A in combination with a regulatory beta subunit responds to depolarization by opening and passively transporting sodium ions according to the concentration gradient from the extracellular region to the cytosol (Ahmed et al. 1992, Ben-Shalom et al. 2017). In mouse type II taste cells, initial depolarization at the apex of the cell is believed to cause an activation potential via Scn2a, Scn3a, and Scn9a located at the basolateral membrane (Gao et al. 2009). Differences in SCN2A alleles appear to be related to autism spectrum disorder (Ben-Shalom et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
1325650	Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain Evans, GA, McPherson, JD, Ferrer-Montiel, AV, Wasmuth, JJ, Schinder, AF, Ahmed, CM, Wagner-McPherson, CB, Patten, CD, Lee, SC, Ware, DH	Proc Natl Acad Sci U S A	1992
28256214	Opposing Effects on Na_V1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures Berrios, KN, Ben-Shalom, R, Bender, KJ, Keeshen, CM, Sanders, SJ, An, JY	Biol Psychiatry	2017