CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region

Stable Identifier
R-HSA-9717392
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region
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The CALHM1 channel transports ATP across the plasma membrane in response to depolarization of the membrane (Taruno et al. 2013). Heteromeric complexes containing both CALHM1 and CALHM3 have voltage-gating that is faster than homomeric CALHM1 complexes and resembles the voltage gating observed in taste cells in vivo (Ma et al. 2018). In mice, knockout of Calhm1 strongly affected voltage-gated currents associated with ATP release and Calhm1 and Calhm3 are sorted to the basolateral membrane of taste cells.
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Output
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as an event of
Catalyst Activity

ATP transmembrane transporter activity of CALHM1:CALHM3 [plasma membrane]

Physical Entity
CALHM1:CALHM3 [plasma membrane] (Homo sapiens)
Activity
ATP transmembrane transporter activity (GO:0005347)
This event is regulated
Positively by
Regulator
Na+ [cytosol]
Inferred From
Calhm1:Calhm3 transports ATP from the cytosol to the extracellular region (Mus musculus)
Cross References
Rhea
Authored
May, B  (2021-03-08)
Reviewed
Jiang, P  (2021-08-08)
Created
May, B  (2021-03-10)
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