ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol

Stable Identifier
R-HSA-9717215
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Upon binding IP3, ITPR3 transports calcium ions across the endoplasmic reticulum membrane according to the concentration gradient from the ER lumen to the cytosol (Lock et al. 2018). The mouse homolog of ITPR3 is expressed in type II (umami, sweet, bitter) taste cells where it responds to IP3 produced by PLCB2 (Hisatsune et al. 2007).

Literature References
PubMed ID Title Journal Year
30563861 All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics

Lock, JT, Alzayady, KJ, Yule, DI, Parker, I

Sci Signal 2018
Participants
Participates
Catalyst Activity

calcium-release channel activity of IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]

Orthologous Events
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