ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol

Stable Identifier
R-HSA-9717215
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol
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Upon binding IP3, ITPR3 transports calcium ions across the endoplasmic reticulum membrane according to the concentration gradient from the ER lumen to the cytosol (Lock et al. 2018). The mouse homolog of ITPR3 is expressed in type II (umami, sweet, bitter) taste cells where it responds to IP3 produced by PLCB2 (Hisatsune et al. 2007).
Literature References
PubMed ID Title Journal Year
30563861 All three IP3 receptor isoforms generate Ca2+ puffs that display similar characteristics

Parker, I, Yule, DI, Alzayady, KJ, Lock, JT

Sci Signal 2018
Participants
Input
Output
Participates
as an event of
Catalyst Activity

intracellularly gated calcium channel activity of IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]

Physical Entity
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
intracellularly gated calcium channel activity (GO:0015278)
Orthologous Events
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Bos taurus)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Caenorhabditis elegans)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Dictyostelium discoideum)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Drosophila melanogaster)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Mus musculus)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Rattus norvegicus)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Sus scrofa)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
May, B  (2021-03-05)
Reviewed
Jiang, P  (2021-08-08)
Created
May, B  (2021-03-08)
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