RAC2 binds effectors at the mitochondrial outer membrane

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAC2 interacts with several effectors localized at the mitochondrial outer membrane. Since RAC2 localization at the mitochondrial outer membrane and its association with mitochondrial proteins has not been fully established, these effectors are annotated as candidates:
ARMCX3 (Bagci et al. 2020)
MTX1 (Capala et al. 2015)
SAMM50 (Capala et al. 2015)

Literature References
PubMed ID Title Journal Year
26016997 Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2

Schuringa, JJ, Vellenga, E, Kuipers, J, Bonardi, F, Giepmans, BN, van den Boom, V, Capala, ME, Maat, H

PLoS One 2015
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP

Nat. Cell Biol. 2020
Orthologous Events
Cite Us!