RHOC activates endoplasmic reticulum effectors

Stable Identifier
R-HSA-9714361
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RHOC activates endoplasmic reticulum effectors
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on the high throughput screen conducted by Bagci et al. 2020, constitutively active RHOC binds to the following candidate effectors, known to reside at the endoplasmic reticulum membrane:
LBR (Bagci et al. 2020)
LMAN1 (Bagci et al. 2020)
MACO1 (Bagci et al. 2020)
PGRMC2 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
VAPB (Bagci et al. 2020)
Literature References
PubMed ID Title Journal Year
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
Participants
Input
Output
Participates
as an event of
Orthologous Events
RHOC activates endoplasmic reticulum effectors (Bos taurus)
RHOC activates endoplasmic reticulum effectors (Canis familiaris)
RHOC activates endoplasmic reticulum effectors (Gallus gallus)
RHOC activates endoplasmic reticulum effectors (Mus musculus)
RHOC activates endoplasmic reticulum effectors (Saccharomyces cerevisiae)
RHOC activates endoplasmic reticulum effectors (Schizosaccharomyces pombe)
RHOC activates endoplasmic reticulum effectors (Sus scrofa)
Authored
Orlic-Milacic, M  (2020-07-14)
Reviewed
Fort, P  (2021-02-05)
Created
Orlic-Milacic, M  (2021-02-10)
Cite Us!