SHC-binding ALK mutant dimers [cytosol]

Stable Identifier
R-HSA-9713538
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
18923523 Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

Schleiermacher, G, Lequin, D, Pierron, G, de Pontual, L, Michon, J, Valteau-Couanet, D, Amiel, J, Raynal, V, Delattre, O, Puisieux, A, Lyonnet, S, Ribeiro, A, Frebourg, T, Combaret, V, Janoueix-Lerosey, I, Brugières, L

Nature 2008
21838707 Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684

Schönherr, C, Eriksson, T, Christensen, J, Palmer, RH, Hallberg, B, Ruuth, K, Yamazaki, Y

Biochem J 2011
21596819 Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene

Xing, M, Murugan, AK

Cancer Res. 2011
23104988 Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma

Ohira, M, Marra, MA, Palmer, RH, Nakagawara, A, Attiyeh, EF, Schönherr, C, Kogner, P, Sandström, PE, Morozova, O, Martinsson, T, Maris, J, Hallberg, B, Ruuth, K, Yamazaki, Y, Chand, D

Dis Model Mech 2013
11943732 Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity

Bellosillo, B, Morris, SW, Pulford, K, Rosenwald, A, Beà, S, Mason, D, Hernández, L, Pinyol, M, Ott, G, Falini, B, Santos, E, Fernández, A, Carbone, A, Campo, E

Am. J. Pathol. 2002
10706082 A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma

Falini, B, Lanfrancone, L, Campo, E, Trinei, M, Mason, DY, Pelicci, PG, Pulford, K

Cancer Res 2000
18923525 Activating mutations in ALK provide a therapeutic target in neuroblastoma

Zozulya, S, George, RE, Gilliland, DG, Morris, SW, Luther, W, London, WB, Hanna, M, Meyerson, M, McGrady, P, Sanda, T, Gregor, VE, Look, AT, Zhang, J, Fröhling, S, Ahn, Y, Diller, L, Webb, TR, Zhou, W, Greulich, H, Gray, NS, Xue, L

Nature 2008
8633037 Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

Yamamoto, T, Iwahara, T, Satoh, H, Seki, N, Fujimoto, J, Mori, S, Shiota, M

Proc. Natl. Acad. Sci. U.S.A. 1996
22249260 Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma

Hayashi, Y, Chen, Y, Igarashi, T, Hiwatari, M, Takita, J, Ogawa, S, Okubo, J, Nishimura, R, Sanada, M, Kato, M, Oki, K

Oncogene 2012
22570254 Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer

Haack, H, Ren, JM, Gu, TL, Zhu, X, Innocenti, G, Crosby, K, Tan, ZP, Moritz, A, Yang, YF, Ren, H, Rush, J, Beausoleil, S, Comb, MJ, Zhang, Y, Zhou, XM

Cancer Res 2012
23139213 Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma

Louis-Brennetot, C, Schleiermacher, G, Loew, D, Pierron, G, Ferrand, S, Daveau, R, Cappo, J, Vigny, M, Jouannet, S, Delattre, O, Dingli, F, Lombard, B, Boeva, V, Cazes, A, Janoueix-Lerosey, I, Combaret, V, Mazot, P, Barillot, E

Cancer Res 2013
18923524 Oncogenic mutations of ALK kinase in neuroblastoma

Ohira, M, Kikuchi, A, Soda, M, Kato, M, Choi, YL, Nakagawara, A, Hayashi, Y, Wang, L, Ogawa, S, Chen, Y, Sanada, M, Takita, J, Mano, H, Igarashi, T

Nature 2008
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Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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