Reactome | odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1

odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1

Stable Identifier

R-HSA-9712210

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1

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Odorants, volatile chemicals, bind olfactory receptors present in the plasma membrane of cilia of olfactory sensory neurons of the main olfactory epithelium lining the nasal sinus (Wetzel et al. 1999, Keller et al. 2007, Menashe et al. 2007, Schmiedeberg et al. 2007, Cook et al. 2009, Mainland et al. 2014, Gonzalez-Kristeller et al. 2015, Mainland et al. 2015, Geithe et al. 2017, Noe et al. 2017, Sanmarti-Espinal et al. 2017, Trimmer et al. 2019). Each olfactory sensory neuron expresses one olfactory receptor gene and each olfactory receptor binds a particular set of odorants, usually members of a family of chemicals containing characteristic chemical groups such as aldehydes (Mainland et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
24316890	The missense of smell: functional variability in the human odorant receptor repertoire Li, YR, Moberly, AH, Matsunami, H, Lin, A, Adipietro, KA, Zhan, S, Snyder, LL, Keller, A, Zhuang, H, Zhou, T, Trimmer, C, Mainland, JD, Liu, WL, Lee, SS	Nat Neurosci	2014
25977809	Human olfactory receptor responses to odorants Li, YR, Matsunami, H, Zhou, T, Mainland, JD, Liu, WL	Sci Data	2015
28656349	Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1 Geithe, C, Protze, J, Krause, G, Kreuchwig, F, Krautwurst, D	Cell Mol Life Sci	2017
25784876	Identification of agonists for a group of human odorant receptors Galante, PA, Gonzalez-Kristeller, DC, Malnic, B, do Nascimento, JB	Front Pharmacol	2015
10460249	Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes Hatt, H, Wetzel, CH, Gisselmann, G, Kuczkowiak, M, Wellerdieck, C, Oles, M	J Neurosci	1999
17601748	Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2 Weber, HP, Meyerhof, W, Schilling, B, Schmiedeberg, K, Krautwurst, D, Shirokova, E	J Struct Biol	2007
27916748	OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol Geithe, C, Polster, J, Kotthoff, M, Krautwurst, D, Schieberle, P, Noe, F	Chem Senses	2017
17973576	Genetic elucidation of human hyperosmia to isovaleric acid Lancet, D, Luetje, CW, Abaffy, T, Yahalom, V, Hasin, Y, Goshen, S, Menashe, I	PLoS Biol	2007
17873857	Genetic variation in a human odorant receptor alters odour perception Keller, A, Vosshall, LB, Chi, Q, Matsunami, H, Zhuang, H	Nature	2007
19581598	Large-scale production and study of a synthetic G protein-coupled receptor: human olfactory receptor 17-4 Vogel, H, Vanberghem, M, Kaiser, L, Zhang, S, Herlihy, K, Cook, BL, Berke, AP, Pick, H, Graveland-Bikker, J, Steuerwald, D	Proc Natl Acad Sci U S A	2009
27916747	The Broadly Tuned Odorant Receptor OR1A1 is Highly Selective for 3-Methyl-2,4-nonanedione, a Key Food Odorant in Aged Wines, Tea, and Other Foods Geithe, C, Krautwurst, D, Noe, F, Kreissl, J	Chem Senses	2017
31040214	Genetic variation across the human olfactory receptor repertoire alters odor perception Keller, A, Matsunami, H, Murphy, NR, Vosshall, LB, Katsanis, N, Nagai, MH, Mainland, JD, Willer, JR, Trimmer, C, Snyder, LL	Proc Natl Acad Sci U S A	2019
29235485	Quantification of interacting cognate odorants with olfactory receptors in nanovesicles Iavicoli, P, Marco, MP, Sanmartí-Espinal, M, Galve, R, Taulés, M, Calò, A, Samitier, J	Sci Rep	2017