odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1

Stable Identifier
R-HSA-9712210
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Odorants, volatile chemicals, bind olfactory receptors present in the plasma membrane of cilia of olfactory sensory neurons of the main olfactory epithelium lining the nasal sinus (Wetzel et al. 1999, Keller et al. 2007, Menashe et al. 2007, Schmiedeberg et al. 2007, Cook et al. 2009, Mainland et al. 2014, Gonzalez-Kristeller et al. 2015, Mainland et al. 2015, Geithe et al. 2017, Noe et al. 2017, Sanmarti-Espinal et al. 2017, Trimmer et al. 2019). Each olfactory sensory neuron expresses one olfactory receptor gene and each olfactory receptor binds a particular set of odorants, usually members of a family of chemicals containing characteristic chemical groups such as aldehydes (Mainland et al. 2015).

Literature References
PubMed ID Title Journal Year
25977809 Human olfactory receptor responses to odorants

Mainland, JD, Li, YR, Zhou, T, Liu, WL, Matsunami, H

Sci Data 2015
24316890 The missense of smell: functional variability in the human odorant receptor repertoire

Mainland, JD, Keller, A, Li, YR, Zhou, T, Trimmer, C, Snyder, LL, Moberly, AH, Adipietro, KA, Liu, WL, Zhuang, H, Zhan, S, Lee, SS, Lin, A, Matsunami, H

Nat Neurosci 2014
28656349 Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1

Geithe, C, Protze, J, Kreuchwig, F, Krause, G, Krautwurst, D

Cell Mol Life Sci 2017
25784876 Identification of agonists for a group of human odorant receptors

Gonzalez-Kristeller, DC, do Nascimento, JB, Galante, PA, Malnic, B

Front Pharmacol 2015
10460249 Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes

Wetzel, CH, Oles, M, Wellerdieck, C, Kuczkowiak, M, Gisselmann, G, Hatt, H

J Neurosci 1999
17601748 Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2

Schmiedeberg, K, Shirokova, E, Weber, HP, Schilling, B, Meyerhof, W, Krautwurst, D

J Struct Biol 2007
27916748 OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol

Noe, F, Polster, J, Geithe, C, Kotthoff, M, Schieberle, P, Krautwurst, D

Chem Senses 2017
17973576 Genetic elucidation of human hyperosmia to isovaleric acid

Menashe, I, Abaffy, T, Hasin, Y, Goshen, S, Yahalom, V, Luetje, CW, Lancet, D

PLoS Biol 2007
17873857 Genetic variation in a human odorant receptor alters odour perception

Keller, A, Zhuang, H, Chi, Q, Vosshall, LB, Matsunami, H

Nature 2007
19581598 Large-scale production and study of a synthetic G protein-coupled receptor: human olfactory receptor 17-4

Cook, BL, Steuerwald, D, Kaiser, L, Graveland-Bikker, J, Vanberghem, M, Berke, AP, Herlihy, K, Pick, H, Vogel, H, Zhang, S

Proc Natl Acad Sci U S A 2009
27916747 The Broadly Tuned Odorant Receptor OR1A1 is Highly Selective for 3-Methyl-2,4-nonanedione, a Key Food Odorant in Aged Wines, Tea, and Other Foods

Geithe, C, Noe, F, Kreissl, J, Krautwurst, D

Chem Senses 2017
31040214 Genetic variation across the human olfactory receptor repertoire alters odor perception

Trimmer, C, Keller, A, Murphy, NR, Snyder, LL, Willer, JR, Nagai, MH, Katsanis, N, Vosshall, LB, Matsunami, H, Mainland, JD

Proc Natl Acad Sci U S A 2019
29235485 Quantification of interacting cognate odorants with olfactory receptors in nanovesicles

Sanmartí-Espinal, M, Iavicoli, P, Calò, A, Taulés, M, Galve, R, Marco, MP, Samitier, J

Sci Rep 2017
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