ANO2 dimer binds Ca2+

Stable Identifier
R-HSA-9712195
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Each monomer of the ANO2 dimer (TMEM16B dimer) can bind up to 2 calcium ions at locations in transmembrane helix 6-8 (inferred from mouse Ano1, Tmem16a). The first intracellular loop also plays a role in the calcium sensitivity of ANO2 but the mechanism is unknown as this site does not appear to strongly bind calcium (inferred from mouse Ano1, Tmem16a).

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