ALK fusion proteins bind IRS

Stable Identifier
R-HSA-9712088
Type
Reaction
Species
Homo sapiens
Compartment
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IRS1 binds the NPM-ALK fusion protein through tyrosine residue 167. Mutation of this residue abrogates IRS1 binding, but the NPM-ALK Y167 mutant is still able to support the transforming activity of the fusion protein (Fujimoto et al, 1996).

Literature References
PubMed ID Title Journal Year
8633037 Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

Yamamoto, T, Iwahara, T, Satoh, H, Seki, N, Fujimoto, J, Mori, S, Shiota, M

Proc. Natl. Acad. Sci. U.S.A. 1996
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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