ALK fusions phosphorylate FRS

Stable Identifier
R-HSA-9712087
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ALK fusions phosphorylate FRS
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FRS proteins are phosphorylated downstream of ALK fusions in a manner that depends on ALK kinase activity (Chikamori et al, 2007). FRS binding and activation contributes to the transformation activity of NPM-ALK, possibly by stimulating MAP kinase or PI3K signaling, consistent with established roles in other pathways (reviewed in Palmer et al, 2009; Gotoh, 2008; Sato and Gotoh, 2010).

Literature References
PubMed ID Title Journal Year
19459784 Anaplastic lymphoma kinase: signalling in development and disease

Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B

Biochem. J. 2009
17086210 Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation

Yamamoto, T, Tokai-Nishizumi, N, Fujimoto, J, Chikamori, M

Oncogene 2007
19456272 The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment

Sato, T, Gotoh, N

Expert Opin Ther Targets 2009
18452557 Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

Gotoh, N

Cancer Sci 2008
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of ALK fusions:FRS [cytosol]

Physical Entity
ALK fusions:FRS [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2021-03-22)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2021-01-14)
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