Reactome | CARS1(2-606)-p-7Y-ALK(1058-1620) fusion [cytosol]

CARS1(2-606)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9711977

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cysteine--tRNA ligase, cytoplasmic ecNumber6.1.1.16/ecNumber, SYCC_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        CARS1(2-606)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
        
        CARS1(2-606)-p-7Y-ALK(1058-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
13679433	Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor Debelenko, LV, Arthur, DC, Pack, SD, Helman, LJ, Schrump, DS, Tsokos, M	Lab Invest	2003
12112524	Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor Cools, J, Wlodarska, I, Somers, R, Mentens, N, Pedeutour, F, Maes, B, De Wolf-Peeters, C, Pauwels, P, Hagemeijer, A, Marynen, P	Genes Chromosomes Cancer	2002

External Reference Information

External Reference

UniProt:P49589 CARS1

Gene Names

CARS1, CARS

Chain

initiator methionine:1, chain:2-748

Reference Genes

BioGPS Gene:833 CARS1

COSMIC (genes):CARS CARS1

CTD Gene:833 CARS1

dbSNP Gene:833 CARS1

ENSEMBL:ENSG00000110619 CARS1

HGNC:1493 CARS1

KEGG:hsa:833 CARS1

Monarch:833 CARS1

NCBI Gene:833 CARS1

OMIM:123859 CARS1

UCSC:P49589 CARS1

Reference Transcript

Other Identifiers

11716294_a_at

11737757_a_at

11737758_x_at

16734526

202402_PM_s_at

202402_s_at

212971_PM_at

212971_at

240983_PM_s_at

240983_s_at

3359530

3359531

3359532

3359533

3359534

3359535

3359537

3359538

3359539

3359540

3359545

3359546

3359547

3359548

3359549

3359550

3359552

3359556

3359558

3359559

3359560

3359561

3359562

3359563

3359564

3359567

3359568

3359569

3359570

3359571

3359573

3359574

3359575

3359576

3359577

3359578

3359579

3359580

3359581

3359585

3359593

3359594

3359595

40408_at

69464_at

7945803

833

89954_at

A_24_P95439

GE57570

GO:0000049

GO:0000166

GO:0003723

GO:0003824

GO:0004812

GO:0004817

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0006399

GO:0006412

GO:0006418

GO:0006423

GO:0006520

GO:0016874

GO:0042802

GO:0042803

GO:0046872

GO:0140098

HMNXSV003011256

HMNXSV003028493

Hs.159604.1.A1_3p_a_at

Hs.197927.0.A1_3p_at

Hs.197927.0.A1_3p_s_at

ILMN_1696066

ILMN_2367469

L06845_at

PH_hs_0023636

TC11001289.hg

TC11003010.hg

g10835050_3p_a_at

Participates

as a component of

CARS1(2-606)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

CARS [cytosol]

CARS1(2-606)-ALK(1058-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 607 from UniProt:Q9UM73 ALK

Coordinate

607

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
inflammatory myofibroblastic tumor	DOID:0050905

Cross References

RefSeq

NP_001742.1, NP_001014437.1, NP_644802.1

COSMIC

COSF437

ENSEMBL

ENSP00000278224, ENSG00000110619, ENST00000380525, ENSP00000380300, ENSP00000369897, ENST00000397111, ENST00000633248, ENST00000612826, ENSP00000488657, ENSP00000487923, ENSP00000482336, ENST00000632612, ENSG00000278191, ENST00000278224

OpenTargets

ENSG00000110619

Mondo

0015798

GeneCards

CARS1

HPA

ENSG00000110619-CARS1

PRO

P49589

Pharos - Targets

P49589

GlyGen

P49589

Orphanet

CARS1

HMDB Protein

HMDBP09253

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26641 EEF1G	3	EEF1G [cytosol] (R-HSA-156925) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)	0.527	3

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