5-Methylation of cytosine residues in DNA is a heritable epigenetic mark that regulates gene expression. DNA methyltransferases (DNA MTase, (DNMTs)) catalyze the transfer of the CH3 group from S‑adenosylmethionine (AdoMet) to DNA (Melanie E & Lacey M 2014; Laisne M et al. 2018). DNMTs associate with EZH2 of the Polycomb Repressive Complex 2 (PRC2) (Vire et al. 2006). Aberrant promoter methylation is considered to be a hallmark of cancer (Ehrlich M et al. 2002; Dong Y et al. 2014; Lam K et al. 2016; Croes L et al. 2018). Epigenetic inactivation of GSDME due to hypermethylation of the GSDME promoter region has been linked to tumorigenesis (Akino K et al. 2007; Kim MS et al. 2008a,b; Croes L et al. 2017, 2018; Ibrahim J et al. 2019). Treatment with the DNA methyltransferase inhibitors such as FDA‑approved decitabine (5‑aza‑2'‑deoxycytidine or DAC) may elevate GSDME expression in certain cancer cells (Akino K et al. 2007; Fujikane T et al. 2009).
Kim, MS, Lebron, C, Nagpal, JK, Chae, YK, Chang, X, Huang, Y, Chuang, T, Yamashita, K, Trink, B, Ratovitski, EA, Califano, JA, Sidransky, D
Croes, L, de Beeck, KO, Pauwels, P, Vanden Berghe, W, Peeters, M, Fransen, E, Van Camp, G
Kim, MS, Chang, X, Yamashita, K, Nagpal, JK, Baek, JH, Wu, G, Trink, B, Ratovitski, EA, Mori, M, Sidransky, D
Ibrahim, J, Op de Beeck, K, Fransen, E, Croes, L, Beyens, M, Suls, A, Vanden Berghe, W, Peeters, M, Van Camp, G
methyltransferase activity of DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm]
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