5-Methylation of cytosine residues in DNA is a heritable epigenetic mark that regulates gene expression. DNA methyltransferases (DNA MTase, (DNMTs)) catalyze the transfer of the CH3 group from S‑adenosylmethionine (AdoMet) to DNA (Melanie E & Lacey M 2014; Laisne M et al. 2018). DNMTs associate with EZH2 of the Polycomb Repressive Complex 2 (PRC2) (Vire et al. 2006). Aberrant promoter methylation is considered to be a hallmark of cancer (Ehrlich M et al. 2002; Dong Y et al. 2014; Lam K et al. 2016; Croes L et al. 2018). Epigenetic inactivation of GSDME due to hypermethylation of the GSDME promoter region has been linked to tumorigenesis (Akino K et al. 2007; Kim MS et al. 2008a,b; Croes L et al. 2017, 2018; Ibrahim J et al. 2019). Treatment with the DNA methyltransferase inhibitors such as FDA‑approved decitabine (5‑aza‑2'‑deoxycytidine or DAC) may elevate GSDME expression in certain cancer cells (Akino K et al. 2007; Fujikane T et al. 2009; Wang Y et al. 2017).
de Beeck, KO, Pauwels, P, Croes, L, Van Camp, G, Fransen, E, Vanden Berghe, W, Peeters, M
Yamashita, K, Huang, Y, Chae, YK, Kim, MS, Sidransky, D, Califano, JA, Ratovitski, EA, Nagpal, JK, Trink, B, Chang, X, Lebron, C, Chuang, T
Sidransky, D, Trink, B, Yamashita, K, Baek, JH, Kim, MS, Nagpal, JK, Wu, G, Chang, X, Mori, M, Ratovitski, EA
Suls, A, Croes, L, Van Camp, G, Fransen, E, Vanden Berghe, W, Beyens, M, Ibrahim, J, Peeters, M, Op de Beeck, K
methyltransferase activity of DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm]
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