TP53 or TP63 binds the GSDME gene

Stable Identifier
R-HSA-9710323
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Gasdermin E (GSDME, also known as DFNA5) was identified as a direct target gene of the transcription factor p53 (Masuda Y et al. 2006). Increased expression of GSDME in a human hepatocellular carcinoma cell line (HepG2) treated with H2O2, UV (30 J/m2) or gamma rays (50 Gy) was p53‑dependent. A chromatin immunoprecipitation (ChIP) assay using HepG2 identified a potential p53‑binding site in intron 1 of the GSDME gene. A luciferase reporter gene assay using human non‑small cell lung carcinoma H1299 cells further confirmed that the site is the p53‑responsive sequence involved in the recruitment of TP53 (p53) to the GSDME gene. In addition, P63γ and p73β also upregulated GSDME in human breast cancer MCF7 cells treated with demethylating agent 5‑aza‑2'‑deoxycytidine (DAC), suggesting that the GSDME expression can be regulated by multiple members of the p53 family (Fujikane T et al. 2010).

Literature References
PubMed ID Title Journal Year
16897187 The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage

Masuda, Y, Futamura, M, Kamino, H, Nakamura, Y, Kitamura, N, Ohnishi, S, Miyamoto, Y, Ichikawa, H, Ohta, T, Ohki, M, Kiyono, T, Egami, H, Baba, H, Arakawa, H

J Hum Genet 2006
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