Reactome | CASP4(290-377) [cytosol]

CASP4(290-377) [cytosol]

Stable Identifier

R-HSA-9710096

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CASP4 p20, CASP4_HUMAN, Caspase-4 subunit p20

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Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Regulated Necrosis (Homo sapiens)
  - Pyroptosis (Homo sapiens)
    - CASP4, CASP5 cleave GSDMD (Homo sapiens)
      - activated CASP4, CASP5 [cytosol] (Homo sapiens)
        
        CASP4 tetramer [cytosol] (Homo sapiens)
        
        CASP4(?81-270):CASP4(290-377) [cytosol] (Homo sapiens)
        
        CASP4(290-377) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49662 CASP4

Gene Names

CASP4, ICH2

Chain

initiator methionine:, propeptide:1-80, chain:81-270, propeptide:271-289, chain:290-377

Reference Genes

BioGPS Gene:837 CASP4

COSMIC (genes):CASP4 CASP4

CTD Gene:837 CASP4

dbSNP Gene:837 CASP4

ENSEMBL:ENSG00000196954 CASP4

HGNC:1505 CASP4

KEGG:hsa:837 CASP4

Monarch:837 CASP4

NCBI Gene:837 CASP4

OMIM:602664 CASP4

UCSC:P49662 CASP4

Reference Transcript

Other Identifiers

11716759_a_at

11716760_x_at

11746002_a_at

11748529_x_at

11760221_at

11760222_x_at

11760491_at

195_s_at

209310_PM_s_at

209310_s_at

213596_PM_at

213596_at

3389297

3389298

3389299

3389300

3389301

3389302

3389303

3389304

3389305

3389306

3389307

3389308

3389309

3389310

3389311

3389312

3389313

3389314

3389317

3389318

3389319

3389323

3389325

3389388

75203_r_at

7951372

837

A_23_P35906

A_23_P35912

GE56305

GE589098

GE78972

GO:0001530

GO:0002376

GO:0003824

GO:0004197

GO:0005515

GO:0005576

GO:0005737

GO:0005739

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006508

GO:0006915

GO:0006952

GO:0006954

GO:0008234

GO:0008289

GO:0009617

GO:0012501

GO:0016020

GO:0016540

GO:0016787

GO:0032991

GO:0042742

GO:0042981

GO:0043226

GO:0043525

GO:0045087

GO:0050700

GO:0050727

GO:0050729

GO:0050830

GO:0051604

GO:0061702

GO:0065003

GO:0070059

GO:0070269

GO:0072558

GO:0097193

GO:0098542

GO:0140096

GO:0160074

GO:0160075

GO:1903265

GO:1904646

GO:2000494

HMNXSV003034433

Hs.321247.0.S1_3p_at

Hs.321247.0.S1_3p_x_at

ILMN_1678454

ILMN_1760227

ILMN_1774585

ILMN_1778059

PH_hs_0004239

TC11002246.hg

U28014_at

g886049_3p_s_at

Participates

as a component of

CASP4(?81-270):CASP4(290-377) [cytosol] (Homo sapiens)

Other forms of this molecule

CASP4(?81-270) [cytosol]

CASP4(?-377) [cytosol]

Inferred To

CASP4(290-377) [cytosol] (Gallus gallus)

Casp4 [cytosol] (Mus musculus)

LOC100522887 [cytosol] (Sus scrofa)

CASP13 [cytosol] (Bos taurus)

Cross References

RefSeq

NP_150649.1, XP_016873886.1, NP_001216.1, XP_011541321.1

Guide to Pharmacology - Targets

1620

ENSEMBL

ENST00000444739, ENSP00000376857, ENSP00000388566, ENST00000393150

OpenTargets

ENSG00000196954

HPA

ENSG00000196954-CASP4

ZINC - Substances

CASP4_HUMAN

ZINC target

P49662

PRO

P49662

Pharos - Targets

P49662

ZINC - Predictions - Purchasable

CASP4_HUMAN

HMDB Protein

HMDBP14456

PDB

8J6K, 7WR0, 7WR6, 7WR1, 8SPB, 6NRY, 7WR4, 6KMZ, 7WR5

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