BIL scavenges NO

Stable Identifier
R-HSA-9709885
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Bilirubin (BIL) can serve as an endogenous scavenger of both nitric oxide (NO) and reactive nitrogen species, thus widening the protective role of bilirubin to other reactive species originating within the cellular environment. This ability is quite important in explaining some of the pathophysiological mechanisms involved in the cytoprotective function of the bile pigment against NO-related pathologies such as atherosclerosis, liver disease and neurodegenerative disorders (Mancuso et al, 2006; Kaur et al, 2003; Mancuso et al, 2003).

Literature References
PubMed ID Title Journal Year
12753916 Interaction of bilirubin and biliverdin with reactive nitrogen species

Kaur, H, Hughes, MN, Green, CJ, Naughton, P, Foresti, R, Motterlini, R

FEBS Lett 2003
14637193 Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide

Mancuso, C, Bonsignore, A, Di Stasio, E, Mordente, A, Motterlini, R

Biochem Pharmacol 2003
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