BIL:ALB scavenges O2.-

Stable Identifier
R-HSA-9709883
Type
Reaction [uncertain]
Species
Homo sapiens
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Like unbound bilirubin (BIL) the bilirubin-albumin complex (BlL:ALB) scavenges superoxide. Small amounts of plasma bilirubin are sufficient to prevent oxidation of albumin-bound fatty acids as well as of the protein itself. This indicates a role for BIL:ALB as a physiological antioxidant in plasma and the extravascular space. There is however no evidence for a fully circular mechanism where all bilirubin is oxidized back to biliverdin to be available again as antioxidant (Stocker et al, 1987; Maghzal et al, 2009).

Literature References
PubMed ID Title Journal Year
19690164 Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase

Maghzal, GJ, Leck, MC, Collinson, E, Li, C, Stocker, R

J Biol Chem 2009
3475708 Antioxidant activity of albumin-bound bilirubin

Stocker, R, Glazer, AN, Ames, BN

Proc Natl Acad Sci U S A 1987
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