Reactome | BIL:ALB scavenges O2.-

BIL:ALB scavenges O2.-

Stable Identifier

R-HSA-9709883

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Like unbound bilirubin (BIL) the bilirubin-albumin complex (BlL:ALB) scavenges superoxide. Small amounts of plasma bilirubin are sufficient to prevent oxidation of albumin-bound fatty acids as well as of the protein itself. This indicates a role for BIL:ALB as a physiological antioxidant in plasma and the extravascular space. There is however no evidence for a fully circular mechanism where all bilirubin is oxidized back to biliverdin to be available again as antioxidant (Stocker et al, 1987; Maghzal et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
3475708	Antioxidant activity of albumin-bound bilirubin Ames, BN, Glazer, AN, Stocker, R	Proc Natl Acad Sci U S A	1987
19690164	Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase Li, C, Stocker, R, Maghzal, GJ, Leck, MC, Collinson, E	J Biol Chem	2009