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HSP90:TBK1:IRF3 [cytosol]
Stable Identifier
R-HSA-9709836
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
MAVS:TOMM70:HSP90:TBK1:IRF3 [mitochondrial outer membrane] (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
HSP90 binds TBK1 and IRF3 (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
MAVS:TOMM70:HSP90:TBK1:IRF3 [mitochondrial outer membrane] (Homo sapiens)
HSP90:TBK1:IRF3 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16394098
Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells
Wang, C
,
Sun, S
,
Yang, K
,
Tang, Y
,
Zhang, B
,
Qi, R
,
Shi, H
Mol Biol Cell
2006
Participants
components
HSP90:HSP90 [cytosol]
(Homo sapiens)
IRF3 [cytosol]
(Homo sapiens)
TBK1 [cytosol]
(Homo sapiens)
Participates
as an output of
HSP90 binds TBK1 and IRF3 (Homo sapiens)
as a component of
MAVS:TOMM70:HSP90:TBK1:IRF3 [mitochondrial outer membrane] (Homo sapiens)
as an input of
MAVS:TOMM70 recruits HSP90:TBK1:IRF3 (Homo sapiens)
Inferred To
HSP90:TBK1:IRF3 [cytosol]
(Bos taurus)
HSP90:TBK1:IRF3 [cytosol]
(Canis familiaris)
HSP90:TBK1:IRF3 [cytosol]
(Mus musculus)
HSP90:TBK1:IRF3 [cytosol]
(Rattus norvegicus)
HSP90:TBK1:IRF3 [cytosol]
(Sus scrofa)
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