Impaired BRCA2 binding to PALB2

Stable Identifier
R-HSA-9709603
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Impaired BRCA2 binding to PALB2
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This pathway describes BRCA2 missense mutations that affect the N-terminus of BRCA2 and impair the ability of BRCA2 to bind PALB2, which is a crucial step in homologous recombination repair (HRR) of DNA double-strand breaks (DSBs) (Xia et al. 2006).

Literature References
PubMed ID Title Journal Year
16793542 Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2

Livingston, DM, Couch, FJ, Liu, X, Sheng, Q, Xia, B, Ohashi, A, Nakanishi, K, Christ, N, Jasin, M, Wu, J

Mol Cell 2006
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2020-12-11)
Reviewed
Liu, J  (2022-01-26)
Le, HP  (2022-01-26)
Heyer, WD  (2022-01-26)
Created
Orlic-Milacic, M  (2020-12-16)
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