This pathway describes BRCA2 missense mutations that affect the N-terminus of BRCA2 and impair the ability of BRCA2 to bind PALB2, which is a crucial step in homologous recombination repair (HRR) of DNA double-strand breaks (DSBs) (Xia et al. 2006).
Livingston, DM, Couch, FJ, Liu, X, Sheng, Q, Xia, B, Ohashi, A, Nakanishi, K, Christ, N, Jasin, M, Wu, J
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