Impaired BRCA2 binding to PALB2

Stable Identifier
R-HSA-9709603
Type
Pathway
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
This pathway describes BRCA2 missense mutations that affect the N-terminus of BRCA2 and impair the ability of BRCA2 to bind PALB2, which is a crucial step in homologous recombination repair (HRR) of DNA double-strand breaks (DSBs) (Xia et al. 2006).
Literature References
PubMed ID Title Journal Year
16793542 Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2

Livingston, DM, Couch, FJ, Liu, X, Sheng, Q, Xia, B, Ohashi, A, Nakanishi, K, Christ, N, Jasin, M, Wu, J

Mol Cell 2006
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database
Authored
Reviewed
Created
Cite Us!