CO binds to Cytochrome c oxidase

Stable Identifier
R-HSA-9709406
Type
Reaction [binding]
Species
Homo sapiens
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Carbon monoxide (CO) toxicity is the result of a combination of tissue hypoxia and direct CO-mediated damage at a cellular level, since not all the signs and symptoms presented can be explained only by the formation of carboxyhaemoglobin. CO binds to cytochrome c oxidase, the terminal enzyme in the electron transfer chain, reducing its activity. Regulation of reactive oxygen species (ROS) generation is possibly one of the key components in CO signaling and its interaction with mitochondria but also other heme proteins that generate ROS, such as NADPH oxidase (Alonso et al, 2003; Zuckerbraun et al, 2007; Ishigami et al, 2017; Motterlini and Foresti, 2017).

Literature References
PubMed ID Title Journal Year
28698372 Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature

Ishigami, I, Zatsepin, NA, Hikita, M, Conrad, CE, Nelson, G, Coe, JD, Basu, S, Grant, TD, Seaberg, MH, Sierra, RG, Hunter, MS, Fromme, P, Fromme, R, Yeh, SR, Rousseau, DL

Proc Natl Acad Sci U S A 2017
12969439 Carbon monoxide specifically inhibits cytochrome c oxidase of human mitochondrial respiratory chain

Alonso, JR, Cardellach, F, López, S, Casademont, J, Miró, O

Pharmacol Toxicol 2003
17264172 Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species

Zuckerbraun, BS, Chin, BY, Bilban, M, d'Avila, JC, Rao, J, Billiar, TR, Otterbein, LE

FASEB J 2007
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