Reactome | CO binds to free ferrohemoglobin

CO binds to free ferrohemoglobin

Stable Identifier

R-HSA-9709317

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22427940	Carbon monoxide promotes respiratory hemoproteins iron reduction using peroxides as electron donors Shaklai, M, Sher, EA, Shaklai, N	PLoS One	2012
3427020	Carbon monoxide binding to human hemoglobin A0 Connelly, PR, Di Cera, E, Doyle, ML, Gill, SJ	Biochemistry	1987