CO binds to free ferrohemoglobin

Stable Identifier
R-HSA-9709317
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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CO binds to free ferrohemoglobin
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Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).
Literature References
PubMed ID Title Journal Year
22427940 Carbon monoxide promotes respiratory hemoproteins iron reduction using peroxides as electron donors

Shaklai, M, Sher, EA, Shaklai, N

PLoS One 2012
3427020 Carbon monoxide binding to human hemoglobin A0

Connelly, PR, Di Cera, E, Doyle, ML, Gill, SJ

Biochemistry 1987
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Orthologous Events
CO binds to free ferrohemoglobin (Bos taurus)
CO binds to free ferrohemoglobin (Canis familiaris)
CO binds to free ferrohemoglobin (Danio rerio)
CO binds to free ferrohemoglobin (Gallus gallus)
CO binds to free ferrohemoglobin (Mus musculus)
CO binds to free ferrohemoglobin (Rattus norvegicus)
CO binds to free ferrohemoglobin (Sus scrofa)
CO binds to free ferrohemoglobin (Xenopus tropicalis)
Authored
Stephan, R  (2020-12-03)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-12-14)
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