CO binds to free ferrohemoglobin

Stable Identifier
R-HSA-9709317
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Carbon monoxide (CO) tightly binds to free ferrohemoglobin, preventing its oxidation to methemoglobin by reactive oxygen species. The reaction is fast and quickly removes CO from the local environment if free hemoglobin is present (Cera et al, 1987; Sher et al, 2012).

Literature References
PubMed ID Title Journal Year
3427020 Carbon monoxide binding to human hemoglobin A0

Di Cera, E, Doyle, ML, Connelly, PR, Gill, SJ

Biochemistry 1987
22427940 Carbon monoxide promotes respiratory hemoproteins iron reduction using peroxides as electron donors

Sher, EA, Shaklai, M, Shaklai, N

PLoS One 2012
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