ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)

Stable Identifier
R-HSA-9708812
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)
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ELAC2, the cytosolic ribonuclease responsible for tRNA maturation, cleaves pre-tRNA Ser TGA to create the 3' end of the mature tRNA and a downstream fragment, tRF-1001, which persists in the cytosol (Lee et al. 2009). ELAC2 is also thought to release tRF-1002 from pre-tRNA Asp GTC, tRF-1003 from pre-tRNA Ser GCT, and tRF-1004 from pre-tRNA Asp GTC.

Literature References
PubMed ID Title Journal Year
19933153 A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

Lee, YS, Shibata, Y, Malhotra, A, Dutta, A

Genes Dev 2009
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Catalyst Activity

endoribonuclease activity of ELAC2 [cytosol]

Physical Entity
ELAC2 [cytosol] (Homo sapiens)
Activity
endoribonuclease activity (GO:0004521)
Authored
May, B  (2020-11-29)
Reviewed
Basso, K  (2021-02-13)
Dutta, A  (2021-02-20)
Su, Z  (2021-02-20)
Wilson, B  (2021-02-20)
Created
May, B  (2020-12-01)
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