ELAC2, the cytosolic ribonuclease responsible for tRNA maturation, cleaves pre-tRNA Ser TGA to create the 3' end of the mature tRNA and a downstream fragment, tRF-1001, which persists in the cytosol (Lee et al. 2009). ELAC2 is also thought to release tRF-1002 from pre-tRNA Asp GTC, tRF-1003 from pre-tRNA Ser GCT, and tRF-1004 from pre-tRNA Asp GTC.
Shibata, Y, Dutta, A, Malhotra, A, Lee, YS
endoribonuclease activity of ELAC2 [cytosol]
© 2023 Reactome