Reactome | HMOX1 [nucleoplasm]

HMOX1 [nucleoplasm]

Stable Identifier

R-HSA-9708567

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heme oxygenase 1, HMOX1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9NYP7 ELOVL5

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External Reference Information

External Reference

UniProt:P09601 HMOX1

Gene Names

HMOX1, HO, HO1

Chain

chain:1-288, chain:1-265

Reference Genes

BioGPS Gene:3162 HMOX1

COSMIC (genes):HMOX1 HMOX1

CTD Gene:3162 HMOX1

dbSNP Gene:3162 HMOX1

ENSEMBL:ENSG00000100292 HMOX1

HGNC:5013 HMOX1

KEGG:hsa:3162 HMOX1

Monarch:3162 HMOX1

NCBI Gene:3162 HMOX1

OMIM:141250 HMOX1

UCSC:P09601 HMOX1

Reference Transcript

RefSeq:NM_002133.2 HMOX1

Other Identifiers

11716939_a_at

11753445_a_at

11753446_x_at

16929562

203665_PM_at

203665_at

3162

33802_at

3787029

3944137

3944138

3944139

3944140

3944141

3944142

3944144

3944145

3944146

8072678

A_23_P120883

GE61857

GO:0001525

GO:0001935

GO:0002246

GO:0002376

GO:0002686

GO:0003012

GO:0003824

GO:0004392

GO:0005198

GO:0005515

GO:0005615

GO:0005634

GO:0005654

GO:0005741

GO:0005783

GO:0005789

GO:0005829

GO:0006355

GO:0006357

GO:0006788

GO:0006879

GO:0006914

GO:0006915

GO:0006979

GO:0012501

GO:0014806

GO:0016020

GO:0016236

GO:0016239

GO:0016242

GO:0016491

GO:0019899

GO:0020037

GO:0032722

GO:0034101

GO:0034383

GO:0034605

GO:0035094

GO:0035556

GO:0042060

GO:0042167

GO:0042168

GO:0042542

GO:0042802

GO:0042803

GO:0043123

GO:0043226

GO:0045765

GO:0045766

GO:0046872

GO:0048471

GO:0048661

GO:0048662

GO:0060586

GO:0071243

GO:0071276

GO:0072719

GO:0090050

GO:0110076

GO:1902042

GO:1903589

GO:1904019

GO:1904037

HMNXSV003008800

ILMN_1800512

PH_hs_0011943

TC22000259.hg

TC22001089.hg

X06985_at

g4504436_3p_at

p33878

Participates

as an output of

HMOX1 translocates from the cytosol to the nucleoplasm (Homo sapiens)

Other forms of this molecule

HMOX1 [cytosol]

HMOX1 [endoplasmic reticulum membrane]

HMOX1 [mitochondrial outer membrane]

Inferred To

B0UXS0 [nucleoplasm] (Danio rerio)

Q5E9F2 [nucleoplasm] (Bos taurus)

F1NQF4 [nucleoplasm] (Gallus gallus)

Q9VGJ9 [nucleoplasm] (Drosophila melanogaster)

HMOX1 [nucleoplasm] (Canis familiaris)

hmox1 [nucleoplasm] (Xenopus tropicalis)

P14901 [nucleoplasm] (Mus musculus)

P32394 [nucleoplasm] (Sus scrofa)

P06762 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_002124.1

Guide to Pharmacology - Targets

1441

OpenTargets

ENSG00000100292

ENSEMBL

ENST00000216117, ENSP00000216117

ZINC - Substances

HMOX1_HUMAN

ZINC target

P09601

PRO

P09601

GlyGen

P09601

PDB

3CZY, 3K4F, 1T5P, 1N45, 1N3U, 1OZW, 3HOK, 6EHA, 1OYL, 1OYK, 1XK1, 1XK0, 1XK3, 1NI6, 1XK2, 1S8C, 1XJZ, 4WD4, 1TWR, 1TWN, 1S13, 1OZE, 1OZL, 1OZR, 3TGM, 5BTQ

HPA

ENSG00000100292-HMOX1

Pharos - Targets

P09601

Orphanet

HMOX1

ZINC - Predictions - Purchasable

HMOX1_HUMAN

HMDB Protein

HMDBP00198

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.738	4
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.601	4
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q15800 MSMO1	1	MSMO1 [endoplasmic reticulum membrane] (R-HSA-194648)	0.556	3
UniProt:Q9H5J4 ELOVL6	1	ELOVL6 [endoplasmic reticulum membrane] (R-HSA-548680)	0.556	3
UniProt:Q9NYP7 ELOVL5	1	ELOVL5 [endoplasmic reticulum membrane] (R-HSA-548679)	0.556	3
UniProt:Q53TN4 CYBRD1	1	CYBRD1 [plasma membrane] (R-HSA-917788)	0.556	3
UniProt:Q96DZ7 T4S19			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:O75208 COQ9	1	COQ9 [mitochondrial inner membrane] (R-HSA-8932994)	0.556	3
IntAct:EBI-22344578 CCSB ORF ID			0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q96MV1 TLCD4			0.556	3
UniProt:Q9BY50 SEC11C	1	SEC11C [endoplasmic reticulum membrane] (R-HSA-265065)	0.556	3
UniProt:Q9BUF7-2 CRB3			0.556	3
UniProt:O60669 SLC16A7	1	SLC16A7 [plasma membrane] (R-HSA-373955)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:P49447 CY561			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q8TBP5 F174A			0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q9Y5M8 SRPRB	1	SRPRB [endoplasmic reticulum membrane] (R-HSA-265002)	0.527	2
UniProt:Q9P296 C5AR2	1	C5AR2 [plasma membrane] (R-HSA-964798)	0.527	2
UniProt:Q16880 UGT8	1	UGT8 [endoplasmic reticulum membrane] (R-HSA-9844570)	0.527	3
UniProt:Q9NU19 TB22B			0.527	2
UniProt:Q9BZ11 ADAM33	1	ADAM33 [plasma membrane] (R-HSA-708324)	0.527	2
UniProt:Q9Y6I9 TEX264	2	TEX264 [platelet alpha granule lumen] (R-HSA-8863000) TEX264 [extracellular region] (R-HSA-8863002)	0.527	3
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.508	2

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