Heme regulates transcription by affecting the nucleocytoplasmic shuttling of nuclear protein. Inhibition of heme synthesis enhances the nuclear accumulation of BACH1, whereas treating cells with hemin results in nuclear exclusion of BACH1. A specific region on BACH1 functions as a heme-regulated NES dependent on the exporter Crm1 (XPO1) (Suzuki et al, 2004).
Suzuki, H, Tashiro, S, Hira, S, Sun, J, Yamazaki, C, Zenke, Y, Ikeda-Saito, M, Yoshida, M, Igarashi, K
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