XPO1:BACH1:Hemes are transported out of the nucleus

Stable Identifier
R-HSA-9708423
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Heme regulates transcription by affecting the nucleocytoplasmic shuttling of nuclear protein. Inhibition of heme synthesis enhances the nuclear accumulation of BACH1, whereas treating cells with hemin results in nuclear exclusion of BACH1. A specific region on BACH1 functions as a heme-regulated NES dependent on the exporter Crm1 (XPO1) (Suzuki et al, 2004).

Literature References
PubMed ID Title Journal Year
15175654 Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1

Suzuki, H, Tashiro, S, Hira, S, Sun, J, Yamazaki, C, Zenke, Y, Ikeda-Saito, M, Yoshida, M, Igarashi, K

EMBO J 2004
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