DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid

Stable Identifier
R-HSA-9708408
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid
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DICER1 cleaves the double-stranded RNA hybrid formed by the primer binding site (PBS) of HIV genomic RNA and tRNA Lys UUU, the tRNA that primes reverse transcription of the HIV genome. The products are a tsRNA, PBSncRNA, that is 18 nt of the 3' end of tRNA Lys UUU and an uncharacterized fragment of the HIV genome (Yeung et al. 2009).
Literature References
PubMed ID Title Journal Year
19729508 Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid

Yeung, ML, Jeang, KT, Houzet, L, Bennasser, Y, Watashi, K, Le, SY

Nucleic Acids Res 2009
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Catalyst Activity

ribonuclease III activity of DICER1 [cytosol]

Physical Entity
DICER1 [cytosol] (Homo sapiens)
Activity
ribonuclease III activity (GO:0004525)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
May, B  (2020-11-29)
Reviewed
Wilson, B  (2021-02-20)
Dutta, A  (2021-02-20)
Basso, K  (2021-02-13)
Su, Z  (2021-02-20)
Created
May, B  (2020-11-29)
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