PGRMC2 binds Hemes

Stable Identifier
R-HSA-9707683
Type
Reaction
Species
Homo sapiens
Compartment
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Mitochondria-bound PGRMC1 transfers heme to ER-bound PGRMC2, which delivers heme to proteins in the ER and nucleus, including heme-responsive transcription factors such as Rev-ErbĪ± (Parker et al, 2017; Galmozzi et al, 2020).

Literature References
PubMed ID Title Journal Year
31748741 PGRMC2 is an intracellular haem chaperone critical for adipocyte function

Cintron-Colon, R, Mosure, S, Kojetin, D, Montenegro-Burke, JR, Godio, C, Siuzdak, G, Kim, AS, Webb, WR, Kok, BP, Cravatt, BF, Peluso, JJ, Conti, B, Lee, JY, Galmozzi, A, Solt, LA, Parker, CG, Pru, JK, Albert, V, Spreafico, R, Saez, E

Nature 2019
28111073 Ligand and Target Discovery by Fragment-Based Screening in Human Cells

Sasaki, K, Correia, BE, Lawrence, RM, Joslyn, CM, Johnson, SR, Wang, Y, Kim, AS, Cravatt, BF, Narvaiza, I, Galmozzi, A, Parker, CG, Saez, E, Cavallaro, CL

Cell 2017
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