Hemes:LY96 activates TLR4

Stable Identifier
R-HSA-9707659
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Hemes:LY96 activates TLR4
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Hemes bind and activate TLR4 signaling at amino acids W23 and Y34 on LY96 (MD-2) (Belcher et al, 2002).

Literature References
PubMed ID Title Journal Year
32695117 Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Belcher, JD, Nath, KA, Kiser, ZM, Nguyen, J, Trent, JO, Zhang, P, Vercellotti, GM, Hu, J

Front Immunol 2020
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Orthologous Events
Hemes:LY96 activates TLR4 (Canis familiaris)
Hemes:LY96 activates TLR4 (Gallus gallus)
Hemes:LY96 activates TLR4 (Mus musculus)
Hemes:LY96 activates TLR4 (Sus scrofa)
Authored
Stephan, R  (2020-11-12)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-19)
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