PGRMC2:Hemes translocate to the nucleus

Stable Identifier
R-HSA-9707606
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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PGRMC2 binds heme reversibly. Also, PGRMC2 can bind to AAAS, a subunit of the nuclear pore complex, suggesting nuclear import of the PGRMC2:heme complex through the NPC takes place (Jühlen et al, 2016; Parker et al, 2017; Galmozzi et al 2020).

Literature References
PubMed ID Title Journal Year
27754849 Identification of a novel putative interaction partner of the nucleoporin ALADIN

Jühlen, R, Landgraf, D, Huebner, A, Koehler, K

Biol Open 2016
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