PGRMC2:Hemes translocate to the nucleus

Stable Identifier
R-HSA-9707606
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nuclear envelope, nucleoplasm
ReviewStatus
5/5
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PGRMC2:Hemes translocate to the nucleus
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PGRMC2 binds heme reversibly. Also, PGRMC2 can bind to AAAS, a subunit of the nuclear pore complex, suggesting nuclear import of the PGRMC2:heme complex through the NPC takes place (Jühlen et al, 2016; Parker et al, 2017; Galmozzi et al 2020).
Literature References
PubMed ID Title Journal Year
27754849 Identification of a novel putative interaction partner of the nucleoporin ALADIN

Jühlen, R, Landgraf, D, Koehler, K, Huebner, A

Biol Open 2016
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Orthologous Events
PGRMC2:Hemes translocate to the nucleus (Bos taurus)
PGRMC2:Hemes translocate to the nucleus (Caenorhabditis elegans)
PGRMC2:Hemes translocate to the nucleus (Canis familiaris)
PGRMC2:Hemes translocate to the nucleus (Danio rerio)
PGRMC2:Hemes translocate to the nucleus (Dictyostelium discoideum)
PGRMC2:Hemes translocate to the nucleus (Drosophila melanogaster)
PGRMC2:Hemes translocate to the nucleus (Gallus gallus)
PGRMC2:Hemes translocate to the nucleus (Mus musculus)
PGRMC2:Hemes translocate to the nucleus (Rattus norvegicus)
PGRMC2:Hemes translocate to the nucleus (Saccharomyces cerevisiae)
PGRMC2:Hemes translocate to the nucleus (Schizosaccharomyces pombe)
PGRMC2:Hemes translocate to the nucleus (Sus scrofa)
Authored
Stephan, R  (2020-11-12)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-19)
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