Hemes bind LY96

Stable Identifier
R-HSA-9707594
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Heme binds to MD-2
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Secreted LY96 (MD-2) is a large protein that confers lipopolysaccharide (LPS) sensitivity to Toll-like receptor 4 (TLR4). Hemes can bind to secreted LY96 at a different site than LPS, resulting in comparable TLR4 activation (Belcher et al, 2002; Visintin et al, 2001).

Literature References
PubMed ID Title Journal Year
32695117 Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Belcher, JD, Zhang, P, Nguyen, J, Kiser, ZM, Nath, KA, Hu, J, Trent, JO, Vercellotti, GM

Front Immunol 2020
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!