Hemes bind LY96

Stable Identifier
R-HSA-9707594
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Heme binds to MD-2
ReviewStatus
5/5
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Hemes bind LY96
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Secreted LY96 (MD-2) is a large protein that confers lipopolysaccharide (LPS) sensitivity to Toll-like receptor 4 (TLR4). Hemes can bind to secreted LY96 at a different site than LPS, resulting in comparable TLR4 activation (Belcher et al, 2002; Visintin et al, 2001).
Literature References
PubMed ID Title Journal Year
32695117 Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Belcher, JD, Nath, KA, Kiser, ZM, Nguyen, J, Trent, JO, Zhang, P, Vercellotti, GM, Hu, J

Front Immunol 2020
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Orthologous Events
Hemes bind LY96 (Bos taurus)
Hemes bind LY96 (Canis familiaris)
Hemes bind LY96 (Gallus gallus)
Hemes bind LY96 (Mus musculus)
Hemes bind LY96 (Rattus norvegicus)
Hemes bind LY96 (Sus scrofa)
Authored
Stephan, R  (2020-11-12)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-19)
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