Secreted LY96 (MD-2) is a large protein that confers lipopolysaccharide (LPS) sensitivity to Toll-like receptor 4 (TLR4). Hemes can bind to secreted LY96 at a different site than LPS, resulting in comparable TLR4 activation (Belcher et al, 2002; Visintin et al, 2001).
Belcher, JD, Nath, KA, Kiser, ZM, Nguyen, J, Trent, JO, Zhang, P, Vercellotti, GM, Hu, J
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