Hemes bind LY96

Stable Identifier
R-HSA-9707594
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Heme binds to MD-2
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Hemes bind LY96
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Secreted LY96 (MD-2) is a large protein that confers lipopolysaccharide (LPS) sensitivity to Toll-like receptor 4 (TLR4). Hemes can bind to secreted LY96 at a different site than LPS, resulting in comparable TLR4 activation (Belcher et al, 2002; Visintin et al, 2001).

Literature References
PubMed ID Title Journal Year
32695117 Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Belcher, JD, Zhang, P, Nguyen, J, Kiser, ZM, Nath, KA, Hu, J, Trent, JO, Vercellotti, GM

Front Immunol 2020
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Orthologous Events
Hemes bind LY96 (Canis familiaris)
Hemes bind LY96 (Gallus gallus)
Hemes bind LY96 (Mus musculus)
Hemes bind LY96 (Sus scrofa)
Authored
Stephan, R  (2020-11-12)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-19)
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