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FeHM dissociates from MetHb
Stable Identifier
R-HSA-9707516
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
MetHb releases ferriheme
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
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Heme signaling (Homo sapiens)
FeHM dissociates from MetHb (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Methemoglobin (MetHb) is highly unstable, releasing free ferriheme (FeHM). The hydrophobic ferriheme, if not scavenged by serum proteins, rapidly intercalates into the plasma membrane of surrounding cells, catalyzing lipid oxidation (Balla et al, 1993).
Literature References
PubMed ID
Title
Journal
Year
8415693
Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage
Eaton, JW
,
Balla, G
,
Jacob, HS
,
Vercellotti, GM
,
Balla, J
,
Nath, K
Proc Natl Acad Sci U S A
1993
Participants
Input
MetHb [extracellular region]
(Homo sapiens)
Output
x 2
ApoHb [extracellular region]
(Homo sapiens)
FeHM [extracellular region]
Participates
as an event of
Heme signaling (Homo sapiens)
Orthologous Events
FeHM dissociates from MetHb (Bos taurus)
FeHM dissociates from MetHb (Canis familiaris)
FeHM dissociates from MetHb (Danio rerio)
FeHM dissociates from MetHb (Gallus gallus)
FeHM dissociates from MetHb (Mus musculus)
FeHM dissociates from MetHb (Rattus norvegicus)
FeHM dissociates from MetHb (Sus scrofa)
FeHM dissociates from MetHb (Xenopus tropicalis)
Authored
Stephan, R (2020-11-12)
Reviewed
Somers, J (2021-01-23)
Created
Stephan, R (2020-11-19)
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