FeHM dissociates from MetHb

Stable Identifier
R-HSA-9707516
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
MetHb releases ferriheme
ReviewStatus
5/5
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FeHM dissociates from MetHb
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Methemoglobin (MetHb) is highly unstable, releasing free ferriheme (FeHM). The hydrophobic ferriheme, if not scavenged by serum proteins, rapidly intercalates into the plasma membrane of surrounding cells, catalyzing lipid oxidation (Balla et al, 1993).

Literature References
PubMed ID Title Journal Year
8415693 Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage

Eaton, JW, Balla, G, Jacob, HS, Vercellotti, GM, Balla, J, Nath, K

Proc Natl Acad Sci U S A 1993
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Orthologous Events
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Authored
Stephan, R  (2020-11-12)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-19)
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