Hemes bind to CLEC1B dimer

Stable Identifier
R-HSA-9707505
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Hemes bind to CLEC1B dimer
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Heme is an endogenous agonist for CLEC-2 (CLEC1B) leading to platelet activation through activation of integrin GPIIbIIIa at low concentrations and agglutination at high concentrations (Bourne et al, 2020).
Literature References
PubMed ID Title Journal Year
32354867 Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2

Rayes, J, Watson, SP, Roumenina, LT, Slater, A, Dimitrov, JD, Martin, E, Di, Y, Colicchia, M, Bourne, JH

Haematologica 2020
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Orthologous Events
Hemes bind to CLEC1B dimer (Bos taurus)
Hemes bind to CLEC1B dimer (Caenorhabditis elegans)
Hemes bind to CLEC1B dimer (Canis familiaris)
Hemes bind to CLEC1B dimer (Mus musculus)
Hemes bind to CLEC1B dimer (Rattus norvegicus)
Hemes bind to CLEC1B dimer (Sus scrofa)
Authored
Stephan, R  (2020-11-12)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-19)
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