Hemes bind to CLEC1B dimer

Stable Identifier
R-HSA-9707505
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Hemes bind to CLEC1B dimer
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Heme is an endogenous agonist for CLEC-2 (CLEC1B) leading to platelet activation through activation of integrin GPIIbIIIa at low concentrations and agglutination at high concentrations (Bourne et al, 2020).

Literature References
PubMed ID Title Journal Year
32354867 Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2

Bourne, JH, Colicchia, M, Di, Y, Martin, E, Slater, A, Roumenina, LT, Dimitrov, JD, Watson, SP, Rayes, J

Haematologica 2020
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Orthologous Events
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Hemes bind to CLEC1B dimer (Sus scrofa)
Authored
Stephan, R  (2020-11-12)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-19)
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