Heme is an endogenous agonist for CLEC-2 (CLEC1B) leading to platelet activation through activation of integrin GPIIbIIIa at low concentrations and agglutination at high concentrations (Bourne et al, 2020).
Bourne, JH, Colicchia, M, Di, Y, Martin, E, Slater, A, Roumenina, LT, Dimitrov, JD, Watson, SP, Rayes, J
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