UBXN1 binds BRCA1:BARD1 heterodimer

Stable Identifier
R-HSA-9707051
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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UBXN1 binds BRCA1:BARD1 heterodimer
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The UBXN1 polypeptide can bind to and suppress the E3 ligase activity of autoubiquitinated BRCA1/BARD1 heterodimers. UBXN1 recognizes autoubiquitinated heterodimers through a bipartite interaction in which its UBA domain binds the conjugated K6-linked polyubiquitin chains of BRCA1:BARD1 while its C-terminal region binds BRCA1:BARD1 in a ubiquitin-independent manner.

Literature References
PubMed ID Title Journal Year
20351172 The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function

Baer, R, Ludwig, T, Wu-Baer, F

Mol Cell Biol 2010
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Orthologous Events
UBXN1 binds BRCA1:BARD1 heterodimer (Bos taurus)
UBXN1 binds BRCA1:BARD1 heterodimer (Canis familiaris)
UBXN1 binds BRCA1:BARD1 heterodimer (Mus musculus)
UBXN1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)
UBXN1 binds BRCA1:BARD1 heterodimer (Sus scrofa)
Authored
Baer, RJ  (2020-11-04)
Created
Orlic-Milacic, M  (2020-11-10)
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