SARS-CoV-1 E transports Ca2+

Stable Identifier
R-HSA-9706720
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol, endoplasmic reticulum-Golgi intermediate compartment
ReviewStatus
5/5
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SARS-CoV-1 E transports Ca2+
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Severe acute respiratory syndrome coronavirus type 1(SARS‑CoV‑1) E protein forms Ca2+ permeable protein‑lipid channels in ERGIC/Golgi membranes (Nieto‑Torres JL et al. 2015). Release of Ca2+ from ERGIC/Golgi lumen to the cytosol disrupts Ca2+ balance within cells contributing to the activation of the NLRP3 inflammasome (reviewed by Zhou Y et al. 2020).
Literature References
PubMed ID Title Journal Year
19593379 Structure and inhibition of the SARS coronavirus envelope protein ion channel

Parthasarathy, K, Pervushin, K, Liu, DX, Soong, TW, Yu, D, Vararattanavech, A, Jiang, FL, Torres, J, Lin, X, Tan, E

PLoS Pathog 2009
26331680 Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

Regla-Nava, JA, Jiménez-Guardeño, JM, Enjuanes, L, Fernandez-Delgado, R, Castaño-Rodriguez, C, Aguilella, VM, Verdiá-Báguena, C, Torres, J, Nieto-Torres, JL

Virology 2015
22832120 Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids

DeDiego, ML, Alcaraz, A, Enjuanes, L, Aguilella, VM, Verdiá-Báguena, C, Torres, J, Nieto-Torres, JL

Virology 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

monoatomic cation channel activity of Ub-3xPalmC-E pentamer [endoplasmic reticulum membrane]

Physical Entity
Ub-3xPalmC-E pentamer [endoplasmic reticulum membrane] (Human SARS coronavirus)
Activity
monoatomic cation channel activity (GO:0005261)
Orthologous Events
SARS-CoV-2 E pentamer transports Ca2+ (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Cross References
Rhea
Authored
Shamovsky, V  (2022-02-18)
Reviewed
Messina, F  (2022-02-18)
D'Eustachio, P  (2021-01-26)
Created
Shamovsky, V  (2020-11-09)
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