Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA

Stable Identifier
R-HSA-9706345
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GRB10 promotes signaling through the AKT pathway downstream of active FLT3. GRB10 is recruited to the active receptor by binding to phosphorylated tyrosine residues 572 and 793. Once bound, GRB10 recruits PI3K by direct interaction with the p85 regulatory subunit and subsequent recruitment of catalytic subunit (Kazi and Ronnstrand, 2013; reviewed in Kazi and Ronnstrand, 2019).

Literature References
Participants
Input
Output
Participates
as an event of
Orthologous Events
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Danio rerio)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Gallus gallus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Mus musculus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Xenopus tropicalis)
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-11-04)
Cite Us!