Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA

Stable Identifier
R-HSA-9706345
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
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GRB10 promotes signaling through the AKT pathway downstream of active FLT3. GRB10 is recruited to the active receptor by binding to phosphorylated tyrosine residues 572 and 793. Once bound, GRB10 recruits PI3K by direct interaction with the p85 regulatory subunit and subsequent recruitment of catalytic subunit (Kazi and Ronnstrand, 2013; reviewed in Kazi and Ronnstrand, 2019).

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Orthologous Events
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Bos taurus)
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Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Danio rerio)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Gallus gallus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Mus musculus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-11-04)
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