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Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
Stable Identifier
R-HSA-9706345
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GRB10 promotes signaling through the AKT pathway downstream of active FLT3. GRB10 is recruited to the active receptor by binding to phosphorylated tyrosine residues 572 and 793. Once bound, GRB10 recruits PI3K by direct interaction with the p85 regulatory subunit and subsequent recruitment of catalytic subunit (Kazi and Ronnstrand, 2013; reviewed in Kazi and Ronnstrand, 2019).
Literature References
PubMed ID
Title
Journal
Year
31066629
FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
Kazi, JU
,
Rönnstrand, L
Physiol. Rev.
2019
23246379
FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia
Kazi, JU
,
Rönnstrand, L
Mol Oncol
2013
Participants
Input
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane]
(Homo sapiens)
PIK3CA [cytosol]
(Homo sapiens)
Output
active FLT3:p-Y GRB10:PI3K [plasma membrane]
(Homo sapiens)
Participates
as an event of
FLT3 Signaling (Homo sapiens)
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Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Gallus gallus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Mus musculus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Xenopus tropicalis)
Authored
Rothfels, K (2020-11-06)
Reviewed
Kazi, JU (2020-11-06)
Created
Rothfels, K (2020-11-04)
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