Reactome | SRD5A2 dehydrogenates TEST to DHTEST

SRD5A2 dehydrogenates TEST to DHTEST

Stable Identifier

R-HSA-9705713

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

Testosterone is converted to 5-alpha-dihydroxytestosterone

ReviewStatus

5/5

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The conversion of testosterone to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 2, (SRD5A2) (Andersson et al. 1991). SRD5A2 is highly expressed in the prostate but also in other androgen target sites. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias, also known as male pseudohermaphroditism (Anwar et al. 1997). Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9208814	Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2) Markham, AF, Anwar, R, Gilbey, SG, New, JP	Mol Pathol	1997
1944596	Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism Berman, DM, Andersson, S, Russell, DW, Jenkins, EP	Nature	1991
9536209	A critical review of the origin and control of adrenal androgens Fearon, U, Clarke, D, McKenna, TJ, Cunningham, SK	Baillieres Clin Obstet Gynaecol	1997