SRD5A2 dehydrogenates TEST to DHTEST

Stable Identifier
Reaction [transition]
Homo sapiens
Testosterone is converted to 5-alpha-dihydroxytestosterone
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The conversion of testosterone to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 2, (SRD5A2) (Andersson et al. 1991). SRD5A2 is highly expressed in the prostate but also in other androgen target sites. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias, also known as male pseudohermaphroditism (Anwar et al. 1997). Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).

Literature References
PubMed ID Title Journal Year
9208814 Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2)

Markham, AF, Anwar, R, Gilbey, SG, New, JP

Mol Pathol 1997
1944596 Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism

Berman, DM, Andersson, S, Russell, DW, Jenkins, EP

Nature 1991
9536209 A critical review of the origin and control of adrenal androgens

Fearon, U, Clarke, D, McKenna, TJ, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
Catalyst Activity

3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A2 [endoplasmic reticulum membrane]

This event is regulated
Positively by
Orthologous Events
Cross References
Cite Us!