SRD5A2 dehydrogenates TEST to DHTEST

Stable Identifier
R-HSA-9705713
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Testosterone is converted to 5-alpha-dihydroxytestosterone
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The conversion of testosterone to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 2, (SRD5A2) (Andersson et al. 1991). SRD5A2 is highly expressed in the prostate but also in other androgen target sites. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias, also known as male pseudohermaphroditism (Anwar et al. 1997). Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).

Literature References
PubMed ID Title Journal Year
1944596 Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism

Andersson, S, Berman, DM, Jenkins, EP, Russell, DW

Nature 1991
9208814 Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2)

Anwar, R, Gilbey, SG, New, JP, Markham, AF

Mol Pathol 1997
9536209 A critical review of the origin and control of adrenal androgens

McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A2 [endoplasmic reticulum membrane]
Physical Entity
Activity
This event is regulated
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Orthologous Events
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