SARS-CoV-2 nsp6 binds TBK1

Stable Identifier
R-HSA-9705010
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, double membrane vesicle viral factory outer membrane
ReviewStatus
5/5
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SARS-CoV-2 nsp6 binds TBK1
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Viral infection and stimulation of pattern-recognition receptors such as the toll-like receptor 3 (TLR3) in the endosomes or the RIG-I-like receptors in the cytosol leads to the activation of the IKK-related TANK binding kinase 1 (TBK1). TBK1 in turn phosphorylates the interferon regulatory factor 3 (IRF3). The phosphorylated IRF3 forms a dimer and translocates to the nucleus, activating the transcription of type I IFN (IFN-I) genes (Tu D et al. 2013). Non-structural protein 6 (nsp6) originated from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was found to interact with TBK1 in human embryonic kidney 293 (HEK293) cells, that were co-transfected with plasmids expressing TBK1 and tagged nsp6 (Xia H et al. 2020). Viral nsp6 antagonized IFN-I production in HEK293 cells by binding to TBK1 and suppressing phosphorylation of IRF3 (Xia H et al. 2020).
Literature References
PubMed ID Title Journal Year
32979938 Evasion of Type I Interferon by SARS-CoV-2

Chen, JY, Rajsbaum, R, Zhang, X, Xia, H, Cao, Z, Wang, H, Menachery, VD, Shi, PY, Xie, X

Cell Rep 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Shamovsky, V  (2021-10-27)
Reviewed
Messina, F  (2022-02-18)
Created
Shamovsky, V  (2020-10-21)
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