CHRM2 binds CHRM2 antagonists

Stable Identifier
R-HSA-9704297
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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CHRM2 binds CHRM2 antagonists
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The M2 muscarinic receptors (CHRM2) are expressed mainly in the heart but also in many other tissues. Here, they act to slow the heart rate down by slowing the speed of depolarization. CHRM2 act via a Gi signalling pathway, which causes a decrease in intracellular cAMP leading to inhibitory-type effects (Caulfield & Birdsall 1998). Inhibition of CHRM2 for example by atropine or hyoscyamine will cause a rise in heart rate (Bagshaw et al. 1970).
Literature References
PubMed ID Title Journal Year
5497851 Comparison of atropine and (--)-hyoscyamine on heart rate in man

Chamberlain, DA, Bagshaw, H, Turner, P

Br J Pharmacol 1970
9647869 International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors

Birdsall, NJ, Caulfield, MP

Pharmacol Rev 1998
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Authored
Jassal, B  (2020-10-07)
Reviewed
Huddart, R  (2022-03-01)
Created
Jassal, B  (2020-10-07)
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