Reactome | p-STAT5 dissociates from FLT3 fusion proteinsp-

p-STAT5 dissociates from FLT3 fusion proteinsp-

Stable Identifier

R-HSA-9703432

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

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p-STAT5 dissociates from FLT3 fusion proteinsp-

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Phosphorylated STAT5 is released from the receptor to fulfill its role as a nuclear transcription factor (Grand et al, 2007; Vu et al, 2009; Chonabayshi et al, 2013; reviewed in Murphy and Rani, 2015; Kazi and Roonstrand, 2019).

Literature References

PubMed ID	Title	Journal	Year
19345670	The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation Vu, HA, Xinh, PT, Kano, Y, Tokunaga, K, Sato, Y		2009
31066629	FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications Kazi, JU, Rönnstrand, L	Physiol. Rev.	2019
26716518	STAT5 in Cancer and Immunity Rani, A, Murphy, JJ	J. Interferon Cytokine Res.	2016
17764812	A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy Grand, FH, Iqbal, S, Zhang, L, Russell, NH, Chase, A, Cross, NC		2007
23168613	Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3 Chonabayashi, K, Hishizawa, M, Kawamata, S, Nagai, Y, Ohno, T, Ishikawa, T, Uchiyama, T, Takaori-Kondo, A	Leukemia	2013