tamatinib-resistant FLT3 mutants don't bind tamatinib

Stable Identifier
R-HSA-9703008
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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tamatinib-resistant FLT3 mutants don't bind tamatinib
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The following FLT3 mutants are resistant to tamatinib-mediated inhibition:

FLT3 Y591_V592insVDFREYEYDH (Nguyen et al, 2017)
FLT3 D835A (Nguyen et al, 2017)
FLT3 D835G (Nguyen et al, 2017)
FLT3 D835N (Nguyen et al, 2017)
FLT3 D835Y (Nguyen et al, 2017)

Literature References
PubMed ID Title Journal Year
28077790 FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Levis, M, Nguyen, B, Williams, AB, Small, D, Brown, P, Li, L, Young, DJ, Ma, H

Oncotarget 2017
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as an event of
Normal reaction
FLT3 binds type I TKI (Homo sapiens)
Functional status

Loss of function of tamatinib-resistant FLT3 mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-10-03)
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