sunitinib-resistant FLT3 mutants don't bind sunitinib

Stable Identifier
R-HSA-9702629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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sunitinib-resistant FLT3 mutants don't bind sunitinib
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The following FLT3 mutants are resistant to inhibition by sunitinib:

FLT3 A848P (Albers et al, 2013)
FLT3 D835A (Nguyen et al, 2017)
FLT3 D835G (Nguyen et al, 2017)
FLT3 D835N (Nguyen et al, 2017)
FLT3 D835H (partial: Baker et al, 2013)
FLT3 D835Y (partial: Baker et al, 2013; Nguyen et al, 2017)
FLT3 D835A (Nguyen et al, 2017)

Literature References
PubMed ID Title Journal Year
23392356 The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib

Yu, C, Albers, C, Verbeek, M, Duyster, J, Leischner, H, Illert, AL, von Bubnoff, N, Peschel, C

Leukemia 2013
Participants
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as an event of
Normal reaction
FLT3 binds type II TKI (Homo sapiens)
Functional status

Loss of function of sunitinib-resistant FLT3 mutants [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-10-01)
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