gilteritinib-resistant FLT3 mutants

Stable Identifier
R-HSA-9702590
Type
Pathway
Species
Homo sapiens
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Gilteritinib is a second-generation type I tyrosine kinase inhibitor with activity against FLT3 (reviewed in Daver et al, 2019; Hassanein et l, 2016; Lim et al, 2017; Luxkin et al, 2017). This pathway describes FLT3 mutants that are resistant to inhibition by gilteritinib.

Literature References
PubMed ID Title Journal Year
30651634 Targeting FLT3 mutations in AML: review of current knowledge and evidence

Daver, N, Schlenk, RF, Russell, NH, Levis, MJ

Leukemia 2019
27450971 FLT3 Inhibitors for Treating Acute Myeloid Leukemia

Hassanein, M, Almahayni, MH, Ahmed, SO, Gaballa, S, El Fakih, R

Clin Lymphoma Myeloma Leuk 2016
29069942 Midostaurin/PKC412 for the treatment of newly diagnosed FLT3 mutation-positive acute myeloid leukemia

Luskin, MR, Deangelo, DJ

Expert Rev Hematol 2017
28851395 Molecular targeting in acute myeloid leukemia

Lim, SH, Dubielecka, PM, Raghunathan, VM

J Transl Med 2017
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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Reviewed
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