gilteritinib-resistant FLT3 mutants don't bind gilteritinib

Stable Identifier
R-HSA-9702589
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following FLT3 mutants are resistant to inhibition by gilteritinib:

FLT3 F691L (partial: Mori et al, 2017; Tarver et al, 2020)
FLT3 F691I (partial: Mori et al, 2017)

Literature References
PubMed ID Title Journal Year
32040554 Gilteritinib is a clinically active FLT3 inhibitor with broad activity against FLT3 kinase domain mutations

Tarver, TC, Hill, JE, Rahmat, L, Perl, AE, Bahceci, E, Mori, K, Smith, CC

Blood Adv 2020
28516360 Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia

Mori, M, Kaneko, N, Ueno, Y, Yamada, M, Tanaka, R, Saito, R, Shimada, I, Mori, K, Kuromitsu, S

Invest New Drugs 2017
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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