KW2449-resistant FLT3 mutants don't bind KW2449

Stable Identifier
R-HSA-9702570
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following FLT3 mutants are resistant to inhibition by KW-2449:

FLT3 D835Y (Nguyen et al, 2017; note, Shiotsu et al, 2009 report D835Y as sensitive to KW-2449)

Literature References
PubMed ID Title Journal Year
28077790 FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Levis, M, Nguyen, B, Williams, AB, Small, D, Brown, P, Li, L, Young, DJ, Ma, H

Oncotarget 2017
19541823 KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation

Shimizu, M, Ishikawa, Y, Ishii, K, Shiotsu, Y, Minami, Y, Tanizaki, R, Akiyama, T, Ozeki, K, Akinaga, S, Kanda, Y, Mori, Y, Umehara, H, Kiyoi, H, Naoe, T, Abe, A, Maeda, H, Sato, Y

Blood 2009
Participants
Participates
Normal reaction
Functional status

Loss of function of KW2449-resistant FLT3 mutants [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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