ALK- and STAT3-dependent HIF1A gene expression

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Reaction [BlackBoxEvent]
Homo sapiens
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HIF1A gene expression downstream of ALK signaling is stimulated by binding of phosphorylated STAT3 to the promoter. HIF1A expression contributes to cell growth by supporting angiogenesis and survival under hypoxic conditions (Marzek et al, 2011; Martinengo et al, 20014; reviewed in Werner et al, 2017).

Literature References
PubMed ID Title Journal Year
27879258 Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target

Zhao, C, Wasik, MA, Zhang, Q, Werner, MT

Blood 2017
25193384 ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis

Chiarle, R, Piva, R, Ambrogio, C, Ribatti, D, Ponzoni, M, Menotti, M, Wang, Q, Pastorino, F, Mastini, C, Scalzo, MS, Pellegrino, E, Martinengo, C, Perri, P, Riera, L, Poggio, T, Voena, C

Cancer Res. 2014
21102525 Oncogenic kinase NPM/ALK induces expression of HIF1α mRNA

Zhang, P, Yang, Y, Woetmann, A, Kantekure, K, Liu, X, Odum, N, Wong, W, Cheng, M, Pasha, T, Marzec, M, Wasik, MA

Oncogene 2011
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