Reactome | PRDM1 gene expression downstream of ALK signaling

PRDM1 gene expression downstream of ALK signaling

Stable Identifier

R-HSA-9701548

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PRDM1 gene expression downstream of ALK signaling

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PRDM1 gene expression is repressed by a complex of SIN3A and acetylated, phosphorylated STAT3 dimer downstream of ALK signaling (Gambi et al, 2019). The PRDM1 gene encodes a transcription factor that regulates expression of genes involved in growth inhibition, apoptosis and cell cycle arrest, and PRDM1 has been identified as a tumor suppressor gene in anaplastic large cell lymphoma (ALCL) (Boi et al, 2013; reviewed in Boi et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
24004669	PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma Boi, M, Rinaldi, A, Kwee, I, Bonetti, P, Todaro, M, Tabbò, F, Piva, R, Rancoita, PM, Matolcsy, A, Timar, B, Tousseyn, T, Rodríguez-Pinilla, SM, Piris, MA, Beà, S, Campo, E, Bhagat, G, Swerdlow, SH, Rosenwald, A, Ponzoni, M, Young, KH, Piccaluga, PP, Dummer, R, Pileri, S, Zucca, E, Inghirami, G, Bertoni, F	Blood	2013
30692217	The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3 Gambi, G, Di Simone, E, Basso, V, Ricci, L, Wang, R, Verma, A, Elemento, O, Ponzoni, M, Inghirami, G, Icardi, L, Mondino, A	Cancer Res.	2019
25115512	PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas Boi, M, Zucca, E, Inghirami, G, Bertoni, F	Leuk. Lymphoma	2015