PRDM1 gene expression downstream of ALK signaling

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R-HSA-9701548
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Reaction [BlackBoxEvent]
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Homo sapiens
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PRDM1 gene expression is repressed by a complex of SIN3A and acetylated, phosphorylated STAT3 dimer downstream of ALK signaling (Gambi et al, 2019). The PRDM1 gene encodes a transcription factor that regulates expression of genes involved in growth inhibition, apoptosis and cell cycle arrest, and PRDM1 has been identified as a tumor suppressor gene in anaplastic large cell lymphoma (ALCL) (Boi et al, 2013; reviewed in Boi et al, 2015).

Literature References
PubMed ID Title Journal Year
24004669 PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma

Piva, R, Piris, MA, Tabbò, F, Kwee, I, Inghirami, G, Zucca, E, Bhagat, G, Beà, S, Pileri, S, Piccaluga, PP, Young, KH, Bertoni, F, Dummer, R, Ponzoni, M, Timar, B, Bonetti, P, Todaro, M, Tousseyn, T, Rosenwald, A, Boi, M, Rancoita, PM, Matolcsy, A, Swerdlow, SH, Rodríguez-Pinilla, SM, Campo, E, Rinaldi, A

Blood 2013
30692217 The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3

Verma, A, Inghirami, G, Gambi, G, Wang, R, Elemento, O, Basso, V, Di Simone, E, Mondino, A, Ponzoni, M, Icardi, L, Ricci, L

Cancer Res. 2019
25115512 PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas

Inghirami, G, Bertoni, F, Zucca, E, Boi, M

Leuk. Lymphoma 2015
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