p-Y705, S727 STAT3 dimer binds HIF1A gene

Stable Identifier
R-HSA-9701534
Type
Reaction
Species
Homo sapiens
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STAT3 binds to the HIF1A promoter as assessed by ChIP in NPM-ALK cells. HIF1A expression in turn induces VEGF, which contributes to angiogenesis (Marzec et al, 2011; Martinengo et al, 2014; reviewed in Werner et al, 2017)

Literature References
PubMed ID Title Journal Year
27879258 Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target

Zhao, C, Wasik, MA, Zhang, Q, Werner, MT

Blood 2017
25193384 ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis

Chiarle, R, Piva, R, Ambrogio, C, Ribatti, D, Ponzoni, M, Menotti, M, Wang, Q, Pastorino, F, Mastini, C, Scalzo, MS, Pellegrino, E, Martinengo, C, Perri, P, Riera, L, Poggio, T, Voena, C

Cancer Res. 2014
21102525 Oncogenic kinase NPM/ALK induces expression of HIF1α mRNA

Zhang, P, Yang, Y, Woetmann, A, Kantekure, K, Liu, X, Odum, N, Wong, W, Cheng, M, Pasha, T, Marzec, M, Wasik, MA

Oncogene 2011
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