p-Y705,S727 STAT3 is acetylated

Stable Identifier
R-HSA-9701531
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p-Y705,S727 STAT3 is acetylated
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Phosphorylated STAT3 is acetylated by p300 at lysine 685, stabilizing dimerization and promoter binding (Yuan et al, 2005; reviewed in Yu et al, 2014; Guanizo et al, 2018).
Literature References
PubMed ID Title Journal Year
15653507 Stat3 dimerization regulated by reversible acetylation of a single lysine residue

Yuan, ZL, Chin, YE, Guan, YJ, Chatterjee, D

Science 2005
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Output
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as an event of
Catalyst Activity

protein-lysine-acetyltransferase activity of EP300 [nucleoplasm]

Physical Entity
EP300 [nucleoplasm] (Homo sapiens)
Activity
protein-lysine-acetyltransferase activity (GO:0061733)
Orthologous Events
p-Y705,S727 STAT3 is acetylated (Bos taurus)
p-Y705,S727 STAT3 is acetylated (Caenorhabditis elegans)
p-Y705,S727 STAT3 is acetylated (Canis familiaris)
p-Y705,S727 STAT3 is acetylated (Drosophila melanogaster)
p-Y705,S727 STAT3 is acetylated (Gallus gallus)
p-Y705,S727 STAT3 is acetylated (Mus musculus)
p-Y705,S727 STAT3 is acetylated (Rattus norvegicus)
p-Y705,S727 STAT3 is acetylated (Sus scrofa)
p-Y705,S727 STAT3 is acetylated (Xenopus tropicalis)
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-26)
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