After phosphorylation of Y705 (and in some cases, of S727 in an independent event), STAT3 dimerizes and translocates to the nucleus where it binds to its cognate TTCN(2-4)GGAA site in the promoter of target genes. STAT3-mediated gene expression contributes to cellular proliferation, differentiation and survival (reviwed in Yu et al, 2014; Guanizo et al, 2018).
Gough, DJ, Garama, DJ, Guanizo, AC, Fernando, CD
Jove, R, Buettner, R, Lee, H, Herrmann, A, Yu, H
© 2023 Reactome
