p-Y705, p-S727 STAT3 dimer translocates to the nucleus

Stable Identifier
R-HSA-9701529
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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After phosphorylation of Y705 (and in some cases, of S727 in an independent event), STAT3 dimerizes and translocates to the nucleus where it binds to its cognate TTCN(2-4)GGAA site in the promoter of target genes. STAT3-mediated gene expression contributes to cellular proliferation, differentiation and survival (reviwed in Yu et al, 2014; Guanizo et al, 2018).

Literature References
PubMed ID Title Journal Year
29873274 STAT3: a multifaceted oncoprotein

Gough, DJ, Garama, DJ, Guanizo, AC, Fernando, CD

Growth Factors 2018
25342631 Revisiting STAT3 signalling in cancer: new and unexpected biological functions

Jove, R, Buettner, R, Lee, H, Herrmann, A, Yu, H

Nat. Rev. Cancer 2014
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