Reactome | p-Y705,S727-STAT3 dimerizes

p-Y705,S727-STAT3 dimerizes

Stable Identifier

R-HSA-9701525

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Tyrosine phosphorylation at residue 705 is required for STAT3 dimerization, nuclear translocation, and DNA binding while the function of serine 727 phosphorylation remains largely unknown. The mechanism for serine phosphorylation is independent of tyrosine phosphorylation (reviewed in Yu et al, 2014; Guanizo et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
29873274	STAT3: a multifaceted oncoprotein Gough, DJ, Garama, DJ, Guanizo, AC, Fernando, CD	Growth Factors	2018
25342631	Revisiting STAT3 signalling in cancer: new and unexpected biological functions Jove, R, Buettner, R, Lee, H, Herrmann, A, Yu, H	Nat. Rev. Cancer	2014