Reactome | TRPV1 binds TRPV1 agonists

TRPV1 binds TRPV1 agonists

Stable Identifier

R-HSA-9701064

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Capsaicin is an active component of chili peppers, which are plants belonging to the genus Capsicum. It is a chemical irritant for mammals, including humans. Capsaicin, as a member of the vanilloid family, binds to the vanilloid receptor subtype 1 (TRPV1) (Hayes et al. 2000). TRPV1, which can also be stimulated with heat, protons and physical abrasion, allows Ca2+ influx through the cell membrane when activated. The resulting depolarization of the neuron stimulates signalling to the brain. This whole process is called nociception. Capsaicin and many other natural and synthetic receptor agonists display potential in the relief of chronic pain (Smart et al. 2001, O'Neill et al. 2012, Batiha et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
11301059	Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology Ranson, J, Smart, D, Gunthorpe, MJ, Jerman, JC, Davis, JB, Randall, AD, Hayes, PD, Cairns, W, Brough, SJ	Eur. J. Pharmacol.	2001
11050376	Cloning and functional expression of a human orthologue of rat vanilloid receptor-1 Ellington, K, Sanger, GJ, Clarke, CE, Davis, JB, Meadows, HJ, Terrett, J, Randall, AD, Medhurst, AD, Harries, MH, Barton, AJ, Topp, S, Prinjha, RK, Hayes, P, Jenkins, O, Gunthorpe, MJ, Gloger, IS, Smith, GD, Harrison, DC, Benham, CD, Duckworth, DM, Murdock, P, Cairns, W	Pain	2000